The primary target of action of Comfortis chewable tablets in insects is an activation of nicotinic acetylcholine receptors (nAChRs). Spinosad does not interact with recognised insecticidal binding web-sites of other nicotinic or GABAergic insecticides for example neonicotinoids, fiproles, milbemycins, avermectins, and cyclodienes.If cat only threw